Purpose This systematic review and meta-analysis aimed to investigate the effects of aromatherapy interventions on stroke symptoms in stroke patients. Methods This study adhered to the Preferred Reporting Items of Systematic Reviews and Meta-Analysis guidelines. Relevant studies published between 2004 and 2022 were searched in the PubMed, CINAHL, Cochrane Library, EMBASE, ERIC, and RISS databases. The review included randomized and non-randomized studies of stroke patients who received aromatherapy interventions targeting stroke symptoms. The extracted literature was evaluated via the ROB 2 and ROBINS-1 quality appraisal checklists and visualized using a risk-of-bias visualization tool. Results The review included five randomized controlled trials and five quasi-experimental studies. The results showed that aromatherapy, administered through massage, inhalation, acupressure, mouth care, and olfactory stimulation, was effective in alleviating pain, constipation, oral health, motor power, muscle strength, balance, fatigue, and sleep quality. Aromatherapy also demonstrated beneficial effects in reducing depression, stress, delirium, blood pressure, pulse rate, respiration rate, serum cortisol, and antioxidants, while enhancing happiness, body temperature, and quality of life. A meta-analysis of mean differences in post-test results revealed that three studies reported a significant effect on pain, with an effect size of 1.85 (95% CI, 0.18~3.51). Conclusion Aromatherapy had positive effects on physical, physiological, psychological, cognitive, and integrative health outcomes. We recommend the use of aromatherapy in stroke patients to improve pain relief and health outcomes.
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Purpose This review aimed to evaluate the effectiveness of exercise on Chemotherapy-induced Peripheral Neuropathy (CIPN). Methods The medical databases PubMed, EMBASE, and CINAHL, and several Korean databases were searched until December 2020. Additionally, a manual search was conducted. The risk of bias was assessed using the revised Cochrane risk-of-bias tool for randomized trials. The Review Manager 5.3 version of the Cochrane Library was used to estimate effect size through meta-analysis. Results Nine studies were included. The most common types of exercise reported were yoga, combined aerobics and strength exercise, and combined strength and balance exercise; each was backed by two studies. Four randomized controlled trials were meta-analyzed, and five studies were synthesized qualitatively. A significant effect on CIPN was found using meta-analysis (standardized mean difference=-0.28, 95% confidence interval=-0.47~-0.09, p=.004). As a result of qualitative synthesis, groups that did exercises were reported to have significantly lessened CIPN symptoms than control groups in three studies. In one study, the exercise group showed significant reduction in CIPN symptoms. And in another, the exercise group was more relieved of CIPN symptoms than the control group, although the difference was not significant. Conclusion The results indicate that exercise should be part of the regimen for patients who are receiving or have completed neurotoxic chemotherapy, for relieving CIPN symptoms. However, these results should be interpreted cautiously, especially due to the limited number of studies and the small number of participants. Therefore, further well-designed studies with sufficient numbers of participants are required.
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Purpose This meta-analysis was conducted to analyze the effect of Diabetes Mellitus (DM) on the risk of Parkinson Disease (PD). Methods Original prospective observational studies were searched through PubMed, Cumulative Index of Nursing and Allied Health Literature (CINAHL), ProQuest, Web of Science, Science Direct, Koreanstudies Information Service System (KISS), and DBpia published up to March 2020. The Relative Risks (RRs) were calculated using the random-effects model. Results An integrated analysis of ten large population-based cohort studies, involving 10,730,117 participants, showed that patients with DM had a 30% higher risk of PD than those without DM (pooled RR=1.30, 95% Confidence Interval [CI]=1.14~1.48). Subgroup analyses based on the characteristics of the studies were conducted, and the association between DM and PD was significant in studies conducted in Asia (RR=1.30, 95% CI=1.01~1.69) and Europe (RR=1.45, 95% CI=1.09~1.94), and for patients with DM durations less than ten years (RR=1.31, 95% CI=1.27~1.37) and stroke (RR=1.16, 95% CI=1.03~1.31). Each study included in the analysis had methodologically good quality and showed no evidence of publication bias. Conclusion DM resulted in a significantly increased risk of PD; therefore, prevention and early detection of PD in patients with DM should be encouraged.
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PURPOSE This systematic review and meta-analysis was performed to confirm the effects of exercise on Breast Cancer-Related Lymphedema (BCRL) in breast cancer survivors. METHODS Totally, 1,614 articles were retrieved from databases including PubMed, Ovid MEDLINE, Embase, Cochrane CENTRAL, CINAHL, Korea Med, Kmbase, KISS, NDSL, KiSTi, and academic journals related to nursing in Korea between June 17 and 18, 2019. Fifteen Randomized Controlled Trials (RCTs) were selected for the analysis from June 19 to July 12, 2019. Cochrane's Risk of Bias assessed the quality and risk of bias of selected articles. Review Manager version 5.3 was used for the meta-analysis. RESULTS Studies were published since 2006 including a total of 1,109 participants who were diagnosed with or at risk of BCRL or had undergone surgery for breast cancer treatment. Although exercises were found ineffective for reducing upper extremity edema (Z=0.37, 95% Confidence Interval [CI]=−0.06~0.04, p=.710), they significantly improved shoulder Range of Motion (ROM), especially flexion (Z=5.88, 95% CI=3.06~6.12, p<.001) and abduction (Z=3.41, 95% CI=2.71~10.06, p<.001), upper extremity function (Z=4.02, 95% CI=−12.09~−4.17, p<.001), and Quality of Life (QoL) (Z=3.00, 95% CI=0.13~0.61, p=.003). Egger's regression test assessed publication bias (Intercept=3.75, t=1.79, df=8, p=.111). CONCLUSION Results suggest that exercise is beneficial to BCRL management, especially improvement of shoulder ROM, upper extremity function, and QoL. However, exercise must be performed carefully to prevent side effects. Therefore, nurses should continuously observe signs and symptoms related to BCRL and educate breast cancer survivors on safely performing exercise.
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PURPOSE This study was a systematic review and meta-analysis designed to investigate the variables related to burden of caregivers of people with dementia living at home. METHODS In total, 24 studies were identified through a systematic review and 11 studies met the inclusion criteria for the meta-analysis. EMBASE, MEDLINE (Ovid-MEDLINE, Pubmed) and several Korean databases were searched until April 2018. ‘R 3.5.1’ version was used to analyze the correlated effect sizes. RESULTS According to the results, variables related to caregivers' burden were categorized into factors related to patients and factors related to family caregivers. The effect sizes of correlations between factors associated with patients and caregivers' burden were as follows: problematic behavior & cognition (memory) (.42), problematic behavior (.37), cognition (memory) (.35), stage of dementia (.31), and ability to perform daily life functions (−.27). Factors associated with family caregivers correlated with caregiver burden as follows: health status (−.40), relation (.33), education (.25), time of caring (.24), income (−.21), age (.20), job (−.17), duration of caring (.15), and religion (.14). CONCLUSION Based on the findings, family caregiver needs to preferentialy try to manage problematic behavior & cognition (memory) of dementia and health professionals need to provide comprehensive nursing interventions to improve health for patients with dementia but also family caregivers.
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PURPOSE This study was conducted to explore the factors related to family support for hemodialysis patients. METHODS Preferred Reporting Items Systematic Reviews and Meta-Analysis (PRISMA) flow diagram was used to select 18 studies in Korea for systematic review and meta-analysis. The Effect Sizes of correlation coefficients (ESr) were determined through Fisher's Z transformation. RESULTS The systematic review revealed 31 factors that affect family support(including socio-economic and disease-specific factors) and 23 factors that are influenced by family support (including socio-psychological factors and physiological indicators). In the meta-analysis, 18 factors (10 socio-economic and disease-specific factors and 8 psychological factors and physiological indicators) were used. The socio-economic factors that significantly affected family support were type of medical insurance, perceived economic state, marital status, primary care giver, living together, family monthly income, education level, and job state. Disease-specific factors such as frequency of dialysis per week did not have a significant impact on family support. Family support had a positive influence over patients' self efficacy (ESr=.56), quality of life (ESr=.48), self-esteem(ESr=.42), fatigue (ESr=−.32), sick role behavior (ESr=.32), and depression (ESr=−.24). CONCLUSION This study showed that economic status and family characteristics of hemodialysis patients in Korea affect the level of family support that patients receive, and family support promotes patients' positive psychology and sick role behavior. The results of this study provide useful information in developing family support intervention programs for hemodialysis patients.
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PURPOSE This review aimed to determine the effectiveness of oral care using Chlorhexidine Gluconate (CHX) in Ventilator-Associated Pneumonia (VAP) in the intensive care unit. METHODS An electronic databases search was conducted with Ovid-MEDLINE, EMBASE, CENTRAL, CINAHL and four domestic databases from July 10 to 16, 2018. Two reviewers independently selected the studies; three reviewers assessed their methodological quality and extracted relevant data. We conducted a meta-analysis of the effect of CHX oral care versus placebo using the Review Manager 5.3 software program and summarized the results of intervention from the included studies. RESULTS Of the 512 articles identified, 17 randomized controlled trials met the inclusion criteria for review. The incidence of VAP differed significantly between the CHX and placebo groups (Relative Risk [RR]=0.72, 95% Confidence Interval [CI]=0.63~0.84). The pooled effects of oral care using 0.12% CHX were RR=0.65 (95% CI=0.52~0.80) and RR=0.68 (95% CI=0.54~0.86) using CHX solution, which were statistically significant. When CHX oral care was performed three times a day, the size of the effect was statistically significant (RR=0.63, 95% CI=0.40~0.99). There was no significant difference in mortality between the CHX oral care and placebo groups (RR=1.08, 95% CI=0.94~1.28). CONCLUSION This review provides evidence that performing oral care using a 0.12% CHX solution three times a day could decrease the incidence of VAP. For improving the quality of nursing practice, the results of this review should be used as the basis for the oral care evidence-based practice guidelines for critical patients.
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PURPOSE The purpose of this study was to examine the direction and strength of the relationships between depressive symptoms and Activities of Daily Living (ADLs) among older, cognitively intact adults as reported in observational studies. METHODS A systematic review and meta-analysis were conducted to search the existing published observational studies in five electronic databases. PubMed, EMBASE, PsycINFO, the Cochrane library, CINAHL, and Medline were used from June 2005 to June 2015. The search strategies all used MeSH terms. Studies reporting r-values between depressive symptoms and the ADLs of older adults were included in the meta-analysis. Overall effect size was computed, and subgroup/moderation analysis was then performed. RESULTS 16 studies involving 7,184 older adults were identified, and no publication bias was found. The overall effect size was moderate, with a value of −.28. The strength of the effect size was moderated by sample residence type. CONCLUSION From the meta-analysis results, it was concluded that the strength of the relationship between depressive symptoms and ADLs was significant. The relationship showed a negative direction in all included studies. Therefore, various nursing intervention programs should be developed to increase the ADL related to depression according to the cognitive status and the residence status of the elderly by nurses.
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PURPOSE This systematic review and meta-analysis provided scientific evidence for oral cryotherapy as a nursing intervention for the prevention of Oral Mucositis (OM) associated with Hematopoietic Stem Cell Transplantation (HSCT). METHODS The literature search was carried out in July and October 2017. The MEDLINE, EMBASE, Cochrane Library, CINAHL, and KoreaMed electronic databases were searched using the MeSH keywords “mucositis†and “cryotherapy.†The Cochrane's Risk of Bias tool was used to assess the internal validity of the Randomized Controlled Trials (RCTs). The selected studies were included in the meta-analysis using Review Manager 5.3. RESULTS Among seven RCTs with 264 patients, oral cryotherapy significantly decreased the incidence of OM (Relative Risk [RR]=0.46, 95% Confidence Interval [CI]=0.31~0.66), including severe OM (grade 2~4: RR=0.33, 95% CI=0.21~0.52; grade 3~4: RR=0.34, 95% CI, 0.22~0.53), and also reduced the OM severity score (Standardized Mean Difference [SMD]=−0.92, 95% CI=−1.25~−0.58). In addition, the need of intravenous narcotics therapy (RR=0.19, 95% CI=0.07~0.51) and the total parenteral nutrition (RR=0.54, 95% CI=0.35~0.84) were reduced. These results were associated with a significantly reduced length of hospitalization (Weighted Mean Difference [WMD]=−1.22, 95% CI=−2.37~−0.07). CONCLUSION Oral cryotherapy is effective and well-tolerated nursing intervention to alleviate OM among patients receiving myeloablative therapy before HSCT. Nurses caring for patients treated with myeloablative therapy should place high priority to prevent OM based on this evidence.
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PURPOSE This study was performed to evaluate the effects of non-pharmacological interventions on sleep disturbance amongst adults aged 55 and above. METHODS PubMed, Cochrane Library, EMBASE, CINAHL and several Korean databases were searched. The main search strategy combined terms including non-pharmacological interventions and presence of insomnia. Non-pharmacological interventions included cognitive behavioral therapy, auricular acupuncture, aromatherapy, and emotional freedom techniques. Methodological quality was assessed using Cochrane's Risk of Bias for randomized studies and Risk of Bias Assessment tool for non randomized studies. Data were analyzed by the RevMan 5.3 program of Cochrane Library. RESULTS Sixteen clinical trials met the inclusion criteria with a total of 962 participants. Non-pharmacological interventions was conducted for a mean of 5.5 weeks, 7.7 sessions, and an average of 70 minutes per session. The effects of non-pharmacological interventions on sleep quality (ES=-1.18), sleep efficiency (ES=-1.14), sleep onset latency (ES=-0.88), awakening time after sleep onset (ES=-0.87), and sleep belief (ES=-0.71) were significant, and their effect sizes were ranged from moderate to large. However, the effects on total sleep time and insomnia severity were not significant. CONCLUSION The findings of the current study suggest that non-pharmacological interventions have a positive impact on attitudes and beliefs about sleep, sleep quality, sleep duration, and sleep efficiency. Therefore, the findings of the study provide an evidence to incorporate various non-pharmacological interventions into nursing practice to improve both sleep quality and quantity in patients with insomnia.
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Effects of Psychosocial Interventions on Cortisol and Immune Parameters in Patients with Cancer: A Meta-analysis Pok Ja Oh, Eun-su Jang Journal of Korean Academy of Nursing.2014; 44(4): 446. CrossRef
Effects of Dignity Interventions on Psychosocial and Existential Distress in Terminally ill Patients: A Meta-analysis Pok Ja Oh, Sung-Rae Shin Journal of Korean Academy of Nursing.2014; 44(5): 471. CrossRef
PURPOSE This study was conducted to meta-analyze the effects of hardiness on health-related variables. METHOD: After review of 19 studies performed by Korean nurses, research variables, statistical data(r or F), and other methodological data were extracted and coded. Research variables were categorized under 5 groups such as health-related behavior, well-being, adaptation, stress, and support according to conceptual similarity. Using SAS program, 20 research variables and 34 effect sizes were calculated after eliminating heterogeneous data by Q-test, RESULTS: Effects of hardiness on whole research variables was .512 and ranged from .322 to .643 by categories. The greatest effect was obtained from well-being category, whereas the smallest effect from stress category. All effect sizes were statistically significant. But fail-safe numbers were small and failed to achieve reasonable tolerance level. CONCLUSION: Results of meta-analysis indicated that hardiness has a moderate effect on health-related variables. But for improving the reliability of the results by minimizing publication bias, the more hardiness studies should be done.
A meta-analysis of 13 quasi-experimental studies was conducted to determine the effect of various nursing interventions applied to surgery patients. The studies were selected from dissertations done between 1982 to 1996 and had randomized or nonequivalent control groups in a pretest-post test design. The studies were classified according to three criteria : 1) types of surgery 2) types of nursing interventions 3) types of respondent variables. The following analysis was done : 1) Determination of usefulness of nursing interventions for surgery patients. 2) The magnitude of effect for each study was tested for different types of surgery, nursing interventions and outcome variables. 3) For a group of homogenious studies, the weighted mean effect size and standard error were estimated. Some findings are summarized as follows : Nursing interventions on relaxation effect applied to surgery patients have resulted in a significant effect size on pain, anxiety, and BP stabilization. Relaxation and music therapy were more effective on surgery patients than either education, heat therapy, or purposeful touch. It was impossible to identify which type of surgery was more effected by these interventions. On the basis of these findings, the following recommendations were made : 1) Many studies on the same kind of intervention applied to similar surgery patients should be accumulated continuously to identify factors that affect the effect size. 2) The detailed explanation of research process, such as, assignment method to experimental and control groups, starting points, duration and frequency of nursing interventions, and estimation of the outcome variables should be described in orther to be utilized for further research and practice.