PURPOSE
The purpose of this study was to test a Winningham's psychobiologic entropy model (PEM) on cancer related fatigue (CRF) among patients with solid tumors.
METHODS
Participants consisted of 213 patients with solid tumors recruited from December, 2012 through June, 2013, in a university hospital, in Hwasun, South Korea. Primary symptoms, adjustment, physical activity, status of nutrition and fatigue were measured using structured questionnaires. Collected data were analyzed using SPSS 21.0 and AMOS 21.0 programs.
RESULTS
The modified model tested provided a reasonable fit to the data (χ2=65.80 [df=30, p<.001], TLI=.92, CFI=.95, RMSEA=.08, SRMR=.07). Primary symptoms (dyspnea, anxiety, depression and insomnia) had direct positive effects on CRF. Adjustment and status of nutrition showed indirect negative effects on CRF. However, the impact of physical activity was not significant. These variables explained 49.2% of the variance of CRF among solid tumor patients.
CONCLUSION
The findings demonstrate that the tested model explain some CRF among solid tumor patients and warrant future research considering the cancer-related clinical factors of the given population.

Citations

• Pre-post analysis of a social capital-based exercise adherence intervention for breast cancer survivors with moderate fatigue: a randomized controlled trial
  Sue Kim, Yun Hee Ko, Yoonkyung Song, Min Jae Kang, Hyojin Lee, Sung Hae Kim, Justin Y. Jeon, Young Up Cho, Gihong Yi, Jeehee Han
  Supportive Care in Cancer.2020; 28(11): 5281.     CrossRef