PURPOSE The aim of this study was to impact describe the perception of safety and barriers to adverse drug reactions (ADR) reporting on clinical nurses' monitoring practice for ADR. METHODS A cross-sectional descriptive study was conducted for 270 nurses working at two major general hospitals by convenience sampling. Data were collected using self-report structured questionnaires from May to June, 2017 and analyzed using the SPSS/WIN 22.0 program. RESULTS The nurses' mean score of perceived safety climate was identified towards the hospital organization level (34.41±7.12), towards the work unit level (66.32±9.42), towards the individual level (7.56±1.50) and towards the ADR monitoring practice (32.68±5.42). ADR monitoring practices are positively correlated with that of perceived safety climate at the work unit level and negatively correlated with the barriers to ADR reporting both at the individual and organizational (p < .001) levels. Multiple regression analysis showed that perceived safety climate at the work unit level (β=.37), at the hospital organization level (β=−.18) and the individual barriers to ADR reporting (β=−.42) were found to be predictors of ADR monitoring practice (Adj R2=.36, F=16.38, p < .001). CONCLUSION These findings suggest that an effective educational program needs to be developed to assist the clinical nurses' ADR monitoring practice by improving the nurses' perception of safety climate at the work unit level and reducing the barriers to ADR reporting.
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