Purpose This study was conducted to identify factors affecting person-centered care among tertiary hospital nurses caring for patients with COVID-19. Methods Study participants comprised 152 tertiary hospital nurses with experience caring for patients with COVID-19. Data were collected from September 1 to October 5, 2022 and analyzed using independent t-test, correlation coefficient, and hierarchical multiple regression with SPSS/WIN 26.0. Results Person-centered care showed a statistically significant positive correlation with the nursing work environment (r=.46, p<.001) and teamwork (r=.49, p<.001). Hierarchical multiple regression analysis revealed that the variables of position (β=.20 p=.014) in model 1 (F=6.20, p=.014), teamwork (β=.47 p<.001) in model 2 (F=24.94, p<.001), and teamwork (β=.33 p=.002) in the final model influenced person-centered nursing (F=18.19, p<.001), and the explanatory power was 25.5%. Conclusion The significance of nurses' teamwork has been emphasized because of the COVID-19 pandemic. Teamwork can be promoted by reviewing protocols for responding to severely ill patients with infectious diseases, which were revised during the COVID-19 period, and establishing appropriate systems to follow.