Purpose The purpose of this study was to determine the levels of medication adherence in patients with heart failure and explore the factors related to it. Methods Cross-sectional and descriptive surveys were conducted in 107 patients with heart failure who visited C Hospital in D City. Data were collected from patients using self-report questionnaires between May 2015 and November 2016, and their medical records were identified. Data were analyzed using independent t-test, one-way ANOVA, and correlation and hierarchical multiple regression analyses using SPSS. Results The mean score of medication adherence was 10.23±2.70. Patients with long-term adverse effects showed worse medication adherence than those without long-term adverse effects (t=2.55, p=.012). Medication adherence positively correlated with depression (r=.34, p=.001) and barriers (r=.48, p=.001) but negatively correlated with attitude (r=-.39, p=.001). The hierarchical multiple regression analysis showed that the model with two independent variables of long-term adverse effects (β=-.23, p=.008) and barriers (β=.37, p<.001) explained the 29.6% in medication adherence (F=11.93, p<.001). Conclusion To improve medication adherence, a nursing strategy to reduce long-term adverse effects and barriers accompanied by continuous monitoring is required.
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