Purpose
This study aimed to identify the mediating effect of postoperative pain in the relationship between preoperative anxiety and Postoperative Nausea/Vomiting (PONV) in patients undergoing laparoscopic abdominal surgery.
Methods
The participants were 85 patients who were receiving laparoscopic abdominal surgery and undergoing general anesthesia at a university hospital. Data were collected from September 30 to December 13, 2019 using self-report questionnaires and clinical electronic medical records. The collected data were analyzed with descriptive statistics, independent t-tests, one-way analysis of variance, Pearson's correlation coefficient, and a three-step mediated regression analysis using SPSS/WIN 23.0.
Results
Significant positive correlations were observed between preoperative anxiety and postoperative pain (average score 24 hours after discharge from the recovery room) (r=.38, p<.001), preoperative anxiety and PONV (r=.45, p<.001), and postoperative pain (average score 24 hours after discharge from the recovery room) and PONV (r=.51, p<.001). Postoperative pain had a partial mediating effect (Z=2.28, p=.023) in the relationship between preoperative anxiety and PONV.
Conclusion
To reduce PONV experienced by patients who have undergone laparoscopic abdominal surgery, developing interventions and techniques to manage preoperative anxiety and alleviate postoperative pain is important.

Citations

• Effect of Wrist-Ankle Acupuncture Point Stimulation on Preventing Postoperative Nausea and Vomiting in Female Patients Undergoing Orthopedic Surgery
  Zhenzhen Zhang, Qingge Liu, Rui Chen, Yamin Tian, Chaoping Wang, Di Zhang, Songmei Wu
  Journal of PeriAnesthesia Nursing.2025; 40(3): 634.     CrossRef
• Preoperative Anxiety and Its Postoperative Associated Factors in Patients Receiving Post Anesthetic Recovery Care at Surgical Intensive Care Unit
  Yul Ha Lee, Hye-Ja Park
  Journal of Health Informatics and Statistics.2023; 48(3): 267.     CrossRef

PURPOSE
The purpose of this study was to evaluate the effects of auricular acupressure on nausea, vomiting, and retching in patients with colorectal cancer receiving chemotherapy.
METHODS
A non-equivalent control group with a pretest-posttest design was used. The participants were assigned into either the control or the experimental group. The patients were recruited from November 2013 to March 2014 from a tertiary hospital in Seongnam city, South Korea. A total of 50 patients completed the study. The Korean version of the Index of Nausea, Vomiting, and Retching (INVR) was used.
RESULTS
The experimental group showed significantly lower nausea (p=.011) and retching (p=.014) than did the control group after receiving auricular acupressure. There were significant interaction effects between time and group on auricular acupressure on nausea (F=3.11, p=.009) and retching (F=3.01, p=.010). There were significant interaction effects between time and group on auricular acupressure on total score of INVR (F=8.23, p < .001).
CONCLUSION
Auricular acupressure therapy is effective in relieving nausea and retching after chemotherapy. Auricular acupressure intervention could be used to improve the quality of life for patients with colorectal cancer.

Citations

• The Effectiveness of P6 and Auricular Acupressure as a Complimentary Therapy in Chemotherapy-Induced Nausea and Vomiting Among Patients With Cancer: Systematic Review
  Bushra Alhusamiah, Jumana Almomani, Ahmad Al Omari, Ala’a Abu attallah, Afaf Yousef, Jafar Alasad Alshraideh, Ruqayya S. Zeilani
  Integrative Cancer Therapies.2024;[Epub]     CrossRef
• Evaluation of acupuncture and auriculotherapy in the control of chemotherapy-induced nausea and vomiting: a Pilot Study
  Sabrina Ferreira Monteiro Morais, Ruth Natalia Teresa Turrini
  Revista da Escola de Enfermagem da USP.2023;[Epub]     CrossRef
• Avaliação da acupuntura e auriculoterapia no controle de náuseas e vômitos induzidos por quimioterapia: Estudo Piloto
  Sabrina Ferreira Monteiro Morais, Ruth Natalia Teresa Turrini
  Revista da Escola de Enfermagem da USP.2023;[Epub]     CrossRef
• Aplicabilidade da auriculoterapia em pacientes oncológicos: revisão integrativa da literatura
  Carolina Lélis Venâncio Contim, Fátima Helena do Espírito Santo, Isadora Górski Moretto
  Revista da Escola de Enfermagem da USP.2020;[Epub]     CrossRef

PURPOSE
The purpose of this study was to examine the effects of the evidence-based clinical practice guidelines on Postoperative Nausea and Vomiting (PONV).
METHODS
The research design was a non-equivalent control group with a non-synchronized design. The participants were the patients undergoing gynecologic laparoscopy. Data were collected from July, 2014 through January, 2015. The participants in the experimental group (n=35) received an assessment of risk factors of PONV, aroma therapy, and P6 acupressure method as recommended in the guidelines. Those in the control group (n=35) received usual nursing care. Data were analyzed by mean, standard deviation, t-test, chi2-test using SPSS/WIN 19.0 program.
RESULTS
The occurrence of nausea and vomiting, the level of nausea and vomiting, and the need for antiemetic medicine in the experimental group were significantly less than those in the control group after surgery. The levels of postoperative pain and the amounts of time for nursing activities in the experimental group were significantly reduced than those in the control group after surgery. The levels of satisfaction were significantly higher in the experiment group than that of the control group.
CONCLUSION
The evidence-based guidelines is recommended for nursing practice as a guidance for managing PONV and helping the recovery of patients after laparoscopic surgery.

PURPOSE
The aim of this study was to identify the effects of auricular acupressure on nausea, vomiting and serum serotonin level in gynecological cancer patients with chemotherapy.
METHODS
The research was a randomized control group pretest-posttest design. Participants were 26 patients for the experimental group, and 26 patients for the control group. Auricular acupressure in Shen men, Occiput, Stomach and Sympathetic points was administered to those in the experimental group. Data were analyzed using chi2-test, t-test, ANCOVA, and repeated measures of ANOVA.
RESULTS
The experimental group had reported significantly lower mean nausea NRS (Number Rating Scale), INVR (Index of Nausea, Vomiting, and Retching), and serum serotonin level than those in the control group.
CONCLUSION
Results of the study show auricular acupressure is an effective nursing intervention for reducing chemotherapy-induced nausea, vomiting and serum serotonin level of gynecological cancer patients.

Citations

• The effect of ear acupressure on sexual functioning among lactating women: A randomized sham controlled trial
  Zainab Alimoardi, Sanaz Barghamadi, Terry Oleson, Mohammad Hossein Ayati, Mark D. Griffiths, Nasim Bahrami
  European Journal of Integrative Medicine.2023; 63: 102285.     CrossRef
• The Effect of Self-Acupressure on Peripheral Neuropathy, Disturbance in Daily Activity, and Quality of Life in Breast Cancer Patients undergoing Chemotherapy
  Su Young Kim, Jeong Sook Park
  Asian Oncology Nursing.2021; 21(3): 129.     CrossRef
• The effects of auricular acupressure on the sleep of the elderly using polysomnography, actigraphy and blood test: Randomized, single-blind, sham control
  Juyon Min, Bomi Kim, Hyojung Park
  Complementary Therapies in Clinical Practice.2021; 45: 101464.     CrossRef
• The effect of ear acupressure (auriculotherapy) on sexual function of lactating women: protocol of a randomized sham controlled trial
  Sanaz Barghamadi, Zainab Alimoardi, Terry Oleson, Nasim Bahrami
  Trials.2020;[Epub]     CrossRef
• Effects of Auricular Acupressure on Women With Irritable Bowel Syndrome
  Gee Youn Go, Hyojung Park
  Gastroenterology Nursing.2020; 43(2): E24.     CrossRef
• Effect of Auricular Acupressure on Nausea, Vomiting, and Retching in Patients with Colorectal Cancer Receiving Chemotherapy
  Nayeon Shin, Jummi Park
  Korean Journal of Adult Nursing.2018; 30(3): 227.     CrossRef

PURPOSE
This study was conducted to develop a Cancer Patient Guide with patients involvement using evidenced based practice research. The purpose of this patient guide was to help patients undergoing chemotherapy to manage their nausea and vomiting based on evidence.
METHODS
The design of the research was a methodological study. The participants consisted of seven cancer patients who were asked about their' need for nausea and vomiting management, and secondly, 16 expert & 15 cancer patients to evaluate the Cancer Patient Guide using the DESCERN tool.
RESULTS
1) Sixty-four relevant research evidences based articles were reviewed. 2) Patients were interviewed as to their needs in controlling nausea and vomiting. 3) The preliminary Cancer Patient Guide utilizing the research evidenced and the cancer patients interviews was then evaluated and revised by the experts and cancer patients. Lastly, the Cancer Patient which included an overview of chemotherapy, pathophysiology of nausea & vomiting, pharmacological and non-pharmacological interventions was finalized with each intervention supported by research evidence and patients' narratives of their experience.
CONCLUSION
The Cancer Patient Guide was developed using evidenced based research and cancer patients in-put and be used to improve patients' self-management skill of nausea and vomiting in chemotherapy. The guide t also provides evidence based patient friendly information and contributes as a baseline data for developing and evaluating evidence-based guide for patients.

PURPOSE
The study was done to investigate the effect of ethanol inhalation on postoperative nausea in patients using Patient Controlled Analgesia (PCA).
METHODS
The data were collected from June 1st 2006 to September 30th, 2007. The subjects were 70 patients who had had orthopedic surgery under general anesthesia. The levels of the Visual Analogue Scale (VAS) was used to measure postoperative nausea. The experimental group was given ethanol inhalation using ethanol pads and the control group received normal saline pads. All participants were instructed to take two deep sniffs with the pad one inch from the nose. This was repeated every five minutes for three doses. The collected data were analyzed using SPSS/WIN 12.0 program.
RESULTS
The study supported all hypotheses. "The experimental group given first dose of ethanol inhalation would have a lower level postoperative nausea compared to the control group"(t = -5.900, p = .000). "The experimental group given second doses of ethanol inhalation would have a lower level postoperative nausea compared to the control group"(t = -7.507, p = .000). "The experimental group given third doses of ethanol inhalation would have a lower level postoperative nausea compared to the control group"(t = -6.685, p = .000).
CONCLUSION
According to these results, the ethanol inhalation can be considered an effective nursing intervention for relieving the postoperative nausea in patients using PCA.

PURPOSE
The purpose of this study was to describe the pattern of changes on the score of nausea/vomiting and anxiety during one cycle of chemotherapy. METHOD: A total of 53 subjects who were admitted to C University Hospital for a period of 3 days and 2 nights for chemotherapy were selected from February to April, 2003. Total scores of nausea/vomiting were measured twice a day 3 days for a total of 6 measurements. Anxiety, anorexia, and fatigue were also measured at the first and last measurement points. Data were analyzed by one-way repeated measures, ANOVA, t-test, paired t-test, & Pearson's correlation. RESULT: The score of nausea/vomiting increased over time except for the 4th measurement point but no changes were significant over time. There were the significant differences between 1st and 2nd, and 2nd and 3rd nausea/vomiting score at p < 0.05. The scores of anxiety, anorexia, and fatigue between the first and 6th points were significantly different(t=-5.69, p=.001; t=6.25, p=.0001; t=3.65, p=.0007). CONCLUSION: Further studies are needed to identify the relationship between anxiety, and anticipatory and acute nausea/vomiting respectively.

PURPOSE
The purpose of this study was to examine the effects of aroma oil inhalation using peppermint and bergamot on nausea vomiting and anorexia in cancer patients receiving chemotherapy. METHOD: Study subjects were 30 patients who had experienced nausea and vomiting when they had been hospitalized in K university hospital located in D city after receiving more than two Cisplatin combination chemotherapy treatments. Among them 15 patients were in the experimental group doing aroma oil inhalation and the other 15 patients were in the control group without aroma oil inhalation. The data were collected from February 1, 2002 to May 17, 2002. The data were analyzed with SPSS WIN 10.0 program using frequency, percentage, chi-square-test, t-test, Repeated Measures ANOVA. RESULTS: 1) The degree of nausea and vomiting in the experimental group with aroma oil inhalation using peppermint and bergamot were significantly lower than that of the control group. 2) The degree of anorexia in the experimental group with aroma oil inhalation using peppermint and bergamot were significantly lower than that of the control group. CONCLUSION: aroma oil inhalation was effective for relieving patients' nausea vomiting and anorexia receiving chemotherapy. Therefore, it is proposed that aroma oil inhalation should be applied as a supportive nursing arbitration method to relieve patients' nausea vomiting and anorexia who are receiving chemotherapy.

PURPOSE
This study was conducted to investigate the level of nausea & vomiting, anorexia and food intake during the periods of chemotherapy and 14 days after discharge. METHOD: The subjects were 40 cancer patients(cervix cancer : 20 patients, stomach cancer: 20 patients) who had chemotherapy with Cisplatin & 5-Fu. Data were analyzed by mean & standard deviation, ANCOVA. RESULT: 1. The severity of nausea & vomiting with anorexia in cancer patients receiving chemotherapy was the highest at the 3rd day and then it gradually decreased. At the 14th day after discharge, nausea & vomiting with anorexia still remained with very low levels. 2. The amount of food intake was the lowest on the 3rd day and then gradually increased. However, it was 53.3-72.5% of the ordinary food intake on the 14th day after discharge. Calorie intake was 625.31 Kcal on the 3rd day and 1130.92 Kcal on the 7th day after discharge. 3. There were no significant differences in nausea & vomiting, anorexia, food intake, calory intake between those with cervix cancer and stomach cancer. CONCLUSION: In cancer patients nausea & vomiting and anorexia were severe and food intake was very poor during chemotherapy but afterwards they were gradually improved, but were not completely recovered on the 14th day after discharge. Therefore the nursing intervention regarding the increase of food intake was necessary during chemotherapy and after discharge.

PURPOSE
Purposes of this study were to understand the current trends on complementary therapy in relieving chemotherapy-induced nausea and vomiting and to suggest the future research direction.
METHOD
Subjects were selected on CINAHL, MEDLINE, Korean Academy Data Base from 1980 to 2001 which used nausea, vomiting, chemotherapy and complementary therapy as key words in experimental studies. Eight korean articles and twenty-one international articles were analyzed in terms of general characteristics, research methods, and types of complementary therapy. Data were analyzed by using descriptive statistical methods.
RESULT
Since 2000, researchers have more actively used complementary therapy. In subject characteristics, mean age was 35.5 years old, 45% of the researchers were performed with high level of incidence of chemotherapy induced vomiting, 14% of them set limit of consecutive cycle during research, and 65% of them did not comment the selecting criteria of sample. About 60% of them were designed post-test only control group; 35% used INV by Rhodes, 31% used Likert scale, and 24% used VAS for dependent variable. Muscle relaxation therapy was mostly applied for relief of nausea and vomiting.
CONCLUSION
Further studies will be needed to control extrinsic variables affecting nausea and vomiting in research design and to accumulate evidence with studies applying various complementary therapies.

PURPOSE
The purpose of this study was to investigate the level of nausea, vomiting, anorexia, fatigue and quality of life as well as to determine the relationship between those variables and identify the influencing factors on fatigue and quality of life in stomach cancer patients receiving adjuvant chemotherapy.
METHOD
Subjects were 94 stomach cancer patients undergoing postoperational chemotherapy in a general hospital in Seoul. Nausea and vomiting were measured with Rhodes et al(1984) and anorexia with one 5-point item. Fatigue was measured using Lee's tool(1999) except open questions. The tool for quality of life was modified based on the Quality of Life Index by Padilla et al(1983).
RESULT
Subjects reported low level of fatigue(mean=3.86, range=0-10) compared with the results of previous researches and moderate quality of life(mean=2.64, range=1-4). Fatigue was positively correlated with nausea, vomiting and anorexia(r=.21 ~ .55, p<.05). Quality of life was negatively correlated with nausea, vomiting, anorexia(r= -.24 ~ -.45, p<.05) and fatigue (r=-.61, p<.01). Multiple regression analysis revealed that activity level, vomiting before admission, anorexia during chemotherapy and age explained 52.8% of the variance in fatigue. Fatigue, anorexia before admission, age and sex explained 50.5% of the variance in quality of life. Fatigue and quality of life were not influenced by the stage of disease, nor weight change.
CONCLUSION
These results may contribute to a better understanding of how much the side effects of anticancer drugs can affect fatigue and quality of life in cancer patients undergoing chemotherapy. Also it is the remarkable fact that symptoms remaining after discharge such as vomiting or anorexia continued until re-admission, contributing to patients fatigue and lowered their quality of life.

Nausea, vomiting and retching are universal symptoms that affect individuals' state of health and self-care activities of individuals. Accurate measurements of individual symptoms are required to gather more definitive data, and enhance understanding, planning, and implementation of self-care actions. Recently the Rhodes Index of Nausea, Vomiting, and Retching(INVR), a new format of the INV-2(the Rhodes Index of Nausea and Vomiting), was developed to measure the symptoms of nausea, vomiting and retching in an English speaking population. To determine the reliability and validity of the INVR, and the possibility of using the instrument in Korea, the Korean translation of the INVR and the INV-2 were administered to a convenient sample of 105 patients at two University Hospitals in Kwangju, Korea. The Cronbach's alpha to estimate the internal consistency of reliability for INVR was 0.844. Equivalent measures of reliability were conducted to determine the percentage of agreement and the Spearman rank correlation coefficients for responses on the two instruments. The percent agreement was 83% and the correlation coefficient was 0.906 over all. A significant differences between the INVR scores of the patients with and without nausea, vomiting, or retching were seen, which indicated a construct validity. The INVR was found to be more user friendly for the patient and the healthcare providers. As a result, it is suggested that the INVR can provide a scientific base for measuring the symptoms of nausea, vomiting, and retching for nurses to improve patients' care and quality of life.