Purpose The purpose of this study was to verify the mediating effect of self-care performance between Self-Care Efficacy (SCE) and Health-Related Quality of Life (HRQoL) among patients on primary treatment for pulmonary tuberculosis. Methods A structured self-report survey was conducted with 143 patients on primary treatment for pulmonary tuberculosis. The collected data were analyzed using descriptive statistics, analysis of variance, Pearson correlation coefficient, hierarchical multiple linear regression, and Sobel test. Results There were significant correlations between participants’ SCE and self-care performance (r=.62, p<.001), SCE and HRQoL (r=.44, p<.001), and self-care performance and HRQoL (r=.54, p<.001). Self-care performance completely mediated the relationship between SCE and HRQoL (z=3.72, p<.001). Conclusion It is necessary to develop interventions for reinforcing SCE, focusing on low self-care groups, to ultimately improve the HRQoL of patients on primary treatment for pulmonary tuberculosis.
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