PURPOSE This study was conducted to identify factors associated with oncology nurses' adherence to Chemotherapy-Induced Neutropenia (CIN) guidelines based on Pender's Health Promotion Model (HPM). METHODS For this cross-sectional descriptive study, 187 nurses who worked at the oncology department of Channam National University Hawsun Hospital responded to self-administered questionnaires. A tool for CIN guideline adherence was developed through systematic search, synthesis, translation, and content validation. Data collection was conducted by a trained research assistant from September 18 to September 26, 2017. Data were analyzed using independent t-test, one-way ANOVA, Pearson's correlation coefficient, and stepwise multiple regression. RESULTS Stepwise multiple regression showed that guideline adherence was associated with CIN education (β=.26, p<.001), self-efficacy (β=.17, p=.018), perceived benefits (β=.16, p=.026), interpersonal factors (β=.16, p=.043), and educational level (β=.14, p=.030). CONCLUSION The findings of this study could be used to develop interventions focusing on CIN education and for the strengthening oncology nurses' self-efficacy and beliefs to promote adherence to CIN guidelines. In addition, repeated studies would be needed to verify application of Pender's HPM to explain nurses' adherence.